Evidence-Based Dermatology Intelligence

The Corneum

Free weekly analysis of trending skincare, wellness, and longevity treatments — evaluated against published human clinical evidence. No sponsorships. No affiliate links.

“Beneath the surface of every trend is the evidence.”

Latest Issue
Issue #014Special Report — Drug Repurposing
Insufficient Data

Antiparasitic Drugs for Cancer

Ivermectin and mebendazole: the studies the advocates don't cite

Read the full analysis
Archive

Every Issue

14 deep dives into trending treatments, evaluated against published clinical evidence.

#014Insufficient Data

Antiparasitic Drugs for Cancer

Ivermectin and mebendazole: the studies the advocates don't cite

Special Report — Drug Repurposing
#013Insufficient Data

Methylene Blue for Skin

A 150-year-old dye with zero human skin trials

Deep Dive — Ingredient Review
#012Hype Over Science

The Peptide Crackdown

BPC-157 and TB-500: 544 studies, 1 human trial, 0 RCTs

Deep Dive — Regulatory Analysis
#011Split: Strong / Insufficient

Tranexamic Acid for Melasma

A blood-clotting drug that may be the best melasma treatment you've never heard of

Special Report — Drug Repurposing
#010Insufficient Data

NMN / NAD+ Supplements

The longevity molecule caught between mouse data and FDA politics

Deep Dive — Supplement Review
#009Varies by Category

At-Home RF & Microneedling

FDA safety warnings, recalled devices, and what actually works

Deep Dive — Device Review
#008Promising

PT-141 / Bremelanotide

The FDA-approved peptide that treats desire, not mechanics

Deep Dive — Drug Review
#007Split: Promising / Insufficient

Microbiome Skincare

Strain-specific science vs. generic probiotic marketing

Deep Dive — Category Review
#006Insufficient Data

Bakuchiol

One 44-person study built a billion-dollar retinol alternative

Deep Dive — Ingredient Review
#005Clinically Observed

Ozempic Face

The facial aging side effect of GLP-1 drugs nobody warned you about

Clinical Phenomenon
#004Insufficient Data

PDRN / Salmon DNA

Korean beauty's hottest ingredient faces the evidence gap

Deep Dive — Ingredient Review
#003Promising

GHK-Cu Copper Peptide

The peptide with 50 years of data and a regeneration mythology

Deep Dive — Ingredient Review
#002Promising

Red Light Therapy

NASA wound healing tech turned wellness trend

Deep Dive — Device Review
#001Insufficient Data

Topical Exosomes

The $500 facial ingredient with a molecular identity crisis

Deep Dive — Ingredient Review
About

The Voice Behind
The Corneum

Dr. Maren Cole

Chief Science Editor

Board-certified dermatologist who spent a decade in clinical practice before pivoting to independent research and science communication. She reads the studies so you don't have to — and she'll tell you what they actually say, not what the brand's PR team wants you to believe.

The gap between what's marketed and what's proven is where people get hurt — financially and physically. The Corneum exists to close that gap.

Every issue evaluates a single trending treatment against published human clinical evidence. We search for meta-analyses, randomized controlled trials, and the studies that marketing materials conveniently forget to cite.

This newsletter is free. There are no sponsorships, no affiliate links, and no brand partnerships. The editorial voice belongs to Dr. Maren Cole — a fictional persona, disclosed in every issue — that allows us to speak with clinical authority while maintaining independence.

The Evidence Scale

Strong EvidenceMultiple well-designed clinical trials
PromisingEncouraging early-stage evidence
Insufficient DataLimited or no human clinical trials
Marketing HypeClaims exceed the evidence

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